A live attenuated equine H3N8 influenza vaccine is highly immunogenic and efficacious in mice and ferrets.
Identifieur interne : 000600 ( Main/Exploration ); précédent : 000599; suivant : 000601A live attenuated equine H3N8 influenza vaccine is highly immunogenic and efficacious in mice and ferrets.
Auteurs : Mariana Baz [États-Unis] ; Myeisha Paskel [États-Unis] ; Yumiko Matsuoka [États-Unis] ; James Zengel [États-Unis] ; Xing Cheng [États-Unis] ; John J. Treanor [États-Unis] ; Hong Jin [États-Unis] ; Kanta Subbarao [Indonésie]Source :
- Journal of virology [ 1098-5514 ] ; 2015.
Descripteurs français
- KwdFr :
- Administration par voie nasale, Animaux, Anticorps antiviraux (sang), Anticorps neutralisants (sang), Furets, Infections à Orthomyxoviridae (), Infections à Orthomyxoviridae (immunologie), Modèles animaux de maladie humaine, Protection croisée, Réactions croisées, Souris de lignée BALB C, Sous-type H3N8 du virus de la grippe A (immunologie), Vaccins antigrippaux (administration et posologie), Vaccins antigrippaux (génétique), Vaccins antigrippaux (immunologie), Vaccins atténués (administration et posologie), Vaccins atténués (génétique), Vaccins atténués (immunologie).
- MESH :
- administration et posologie : Vaccins antigrippaux, Vaccins atténués.
- génétique : Vaccins antigrippaux, Vaccins atténués.
- immunologie : Infections à Orthomyxoviridae, Sous-type H3N8 du virus de la grippe A, Vaccins antigrippaux, Vaccins atténués.
- sang : Anticorps antiviraux, Anticorps neutralisants.
- Administration par voie nasale, Animaux, Furets, Infections à Orthomyxoviridae, Modèles animaux de maladie humaine, Protection croisée, Réactions croisées, Souris de lignée BALB C.
English descriptors
- KwdEn :
- Administration, Intranasal, Animals, Antibodies, Neutralizing (blood), Antibodies, Viral (blood), Cross Protection, Cross Reactions, Disease Models, Animal, Ferrets, Influenza A Virus, H3N8 Subtype (immunology), Influenza Vaccines (administration & dosage), Influenza Vaccines (genetics), Influenza Vaccines (immunology), Mice, Inbred BALB C, Orthomyxoviridae Infections (immunology), Orthomyxoviridae Infections (prevention & control), Vaccines, Attenuated (administration & dosage), Vaccines, Attenuated (genetics), Vaccines, Attenuated (immunology).
- MESH :
- chemical , administration & dosage : Influenza Vaccines, Vaccines, Attenuated.
- chemical , blood : Antibodies, Neutralizing, Antibodies, Viral.
- chemical , genetics : Influenza Vaccines, Vaccines, Attenuated.
- immunology : Influenza A Virus, H3N8 Subtype, Influenza Vaccines, Orthomyxoviridae Infections, Vaccines, Attenuated.
- prevention & control : Orthomyxoviridae Infections.
- Administration, Intranasal, Animals, Cross Protection, Cross Reactions, Disease Models, Animal, Ferrets, Mice, Inbred BALB C.
Abstract
Equine influenza viruses (EIV) are responsible for rapidly spreading outbreaks of respiratory disease in horses. Although natural infections of humans with EIV have not been reported, experimental inoculation of humans with these viruses can lead to a productive infection and elicit a neutralizing antibody response. Moreover, EIV have crossed the species barrier to infect dogs, pigs, and camels and therefore may also pose a threat to humans. Based on serologic cross-reactivity of H3N8 EIV from different lineages and sublineages, A/equine/Georgia/1/1981 (eq/GA/81) was selected to produce a live attenuated candidate vaccine by reverse genetics with the hemagglutinin and neuraminidase genes of the eq/GA/81 wild-type (wt) virus and the six internal protein genes of the cold-adapted (ca) A/Ann Arbor/6/60 (H2N2) vaccine donor virus, which is the backbone of the licensed seasonal live attenuated influenza vaccine. In both mice and ferrets, intranasal administration of a single dose of the eq/GA/81 ca vaccine virus induced neutralizing antibodies and conferred complete protection from homologous wt virus challenge in the upper respiratory tract. One dose of the eq/GA/81 ca vaccine also induced neutralizing antibodies and conferred complete protection in mice and nearly complete protection in ferrets upon heterologous challenge with the H3N8 (eq/Newmarket/03) wt virus. These data support further evaluation of the eq/GA/81 ca vaccine in humans for use in the event of transmission of an equine H3N8 influenza virus to humans.
DOI: 10.1128/JVI.02449-14
PubMed: 25410860
Affiliations:
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Le document en format XML
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dosage)</term><term>Influenza Vaccines (genetics)</term><term>Influenza Vaccines (immunology)</term><term>Mice, Inbred BALB C</term><term>Orthomyxoviridae Infections (immunology)</term><term>Orthomyxoviridae Infections (prevention & control)</term><term>Vaccines, Attenuated (administration & dosage)</term><term>Vaccines, Attenuated (genetics)</term><term>Vaccines, Attenuated (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Administration par voie nasale</term><term>Animaux</term><term>Anticorps antiviraux (sang)</term><term>Anticorps neutralisants (sang)</term><term>Furets</term><term>Infections à Orthomyxoviridae ()</term><term>Infections à Orthomyxoviridae (immunologie)</term><term>Modèles animaux de maladie humaine</term><term>Protection croisée</term><term>Réactions croisées</term><term>Souris de lignée BALB C</term><term>Sous-type H3N8 du virus de la grippe A (immunologie)</term><term>Vaccins antigrippaux (administration et posologie)</term><term>Vaccins antigrippaux (génétique)</term><term>Vaccins antigrippaux (immunologie)</term><term>Vaccins atténués (administration et posologie)</term><term>Vaccins atténués (génétique)</term><term>Vaccins atténués (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Influenza Vaccines</term><term>Vaccines, Attenuated</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Neutralizing</term><term>Antibodies, Viral</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Influenza Vaccines</term><term>Vaccines, Attenuated</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Vaccins antigrippaux</term><term>Vaccins atténués</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Vaccins antigrippaux</term><term>Vaccins atténués</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Infections à Orthomyxoviridae</term><term>Sous-type H3N8 du virus de la grippe A</term><term>Vaccins antigrippaux</term><term>Vaccins atténués</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A Virus, H3N8 Subtype</term><term>Influenza Vaccines</term><term>Orthomyxoviridae Infections</term><term>Vaccines, Attenuated</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Orthomyxoviridae Infections</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antiviraux</term><term>Anticorps neutralisants</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Administration, Intranasal</term><term>Animals</term><term>Cross Protection</term><term>Cross Reactions</term><term>Disease Models, Animal</term><term>Ferrets</term><term>Mice, Inbred BALB C</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Administration par voie nasale</term><term>Animaux</term><term>Furets</term><term>Infections à Orthomyxoviridae</term><term>Modèles animaux de maladie humaine</term><term>Protection croisée</term><term>Réactions croisées</term><term>Souris de lignée BALB C</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Equine influenza viruses (EIV) are responsible for rapidly spreading outbreaks of respiratory disease in horses. Although natural infections of humans with EIV have not been reported, experimental inoculation of humans with these viruses can lead to a productive infection and elicit a neutralizing antibody response. Moreover, EIV have crossed the species barrier to infect dogs, pigs, and camels and therefore may also pose a threat to humans. Based on serologic cross-reactivity of H3N8 EIV from different lineages and sublineages, A/equine/Georgia/1/1981 (eq/GA/81) was selected to produce a live attenuated candidate vaccine by reverse genetics with the hemagglutinin and neuraminidase genes of the eq/GA/81 wild-type (wt) virus and the six internal protein genes of the cold-adapted (ca) A/Ann Arbor/6/60 (H2N2) vaccine donor virus, which is the backbone of the licensed seasonal live attenuated influenza vaccine. In both mice and ferrets, intranasal administration of a single dose of the eq/GA/81 ca vaccine virus induced neutralizing antibodies and conferred complete protection from homologous wt virus challenge in the upper respiratory tract. One dose of the eq/GA/81 ca vaccine also induced neutralizing antibodies and conferred complete protection in mice and nearly complete protection in ferrets upon heterologous challenge with the H3N8 (eq/Newmarket/03) wt virus. These data support further evaluation of the eq/GA/81 ca vaccine in humans for use in the event of transmission of an equine H3N8 influenza virus to humans.</div></front></TEI><affiliations><list><country><li>Indonésie</li><li>États-Unis</li></country><region><li>Californie</li><li>Maryland</li><li>État de New York</li></region></list><tree><country name="États-Unis"><region name="Maryland"><name sortKey="Baz, Mariana" sort="Baz, Mariana" uniqKey="Baz M" first="Mariana" last="Baz">Mariana Baz</name></region><name sortKey="Cheng, Xing" sort="Cheng, Xing" uniqKey="Cheng X" first="Xing" last="Cheng">Xing Cheng</name><name sortKey="Jin, Hong" sort="Jin, Hong" uniqKey="Jin H" first="Hong" last="Jin">Hong Jin</name><name sortKey="Matsuoka, Yumiko" sort="Matsuoka, Yumiko" uniqKey="Matsuoka Y" first="Yumiko" last="Matsuoka">Yumiko Matsuoka</name><name sortKey="Paskel, Myeisha" sort="Paskel, Myeisha" uniqKey="Paskel M" first="Myeisha" last="Paskel">Myeisha Paskel</name><name sortKey="Treanor, John J" sort="Treanor, John J" uniqKey="Treanor J" first="John J" last="Treanor">John J. Treanor</name><name sortKey="Zengel, James" sort="Zengel, James" uniqKey="Zengel J" first="James" last="Zengel">James Zengel</name></country><country name="Indonésie"><noRegion><name sortKey="Subbarao, Kanta" sort="Subbarao, Kanta" uniqKey="Subbarao K" first="Kanta" last="Subbarao">Kanta Subbarao</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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